Cold, pain and the brain

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Warm and cold complex regional pain syndromes

Results: Compared with patients who had warm CRPS, patients who had cold CRPS more often reported a history of serious life events (p 0.05) and chronic pain disorders (p 0.05). In cold CRPS, the incidence of CRPS-related dystonia was increased (p 0.05), and cold-induced pain had a higher prevalence (p 0.01). Furthermore, QST revealed a predominant sensory loss in patients with cold CRPS (p 0.05...

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Detection of cold pain, cold allodynia and cold hyperalgesia in freely behaving rats

BACKGROUND Pain is elicited by cold, and a major feature of many neuropathic pain states is that normally innocuous cool stimuli begin to produce pain (cold allodynia). To expand our understanding of cold induced pain states we have studied cold pain behaviors over a range of temperatures in several animal models of chronic pain. RESULTS We demonstrate that a Peltier-cooled cold plate with +/...

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Pain in the brain

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Pain and the brain: specificity and plasticity of the brain in clinical chronic pain.

Descartes proposed that all observable human behavior could be divided into 2 categories, the simple and the complex. Simple behaviors were those in which a given sensation always, deterministically, produced the same behavioral response. . .. Complex behaviors, in contrast were those in which the linkage between sensation and action was unpredictable and subject to the vagaries of volition. . ...

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ژورنال

عنوان ژورنال: Nature

سال: 1995

ISSN: 0028-0836,1476-4687

DOI: 10.1038/373019a0